Other Names: Lopurin, Zurinol

Zyloprim Online - Prescriptions Through AccessMedNet

This treatment effects the removal of purines removal from the body, and decreases the uric acid formation that causes gout. Zyloprim does not interfere with the formation of compounds that are necessary to the body, nor is it used to treat acute attacks of gout.

Zyloprim is an approved treatment for: Long-term preventive gout therapy, prevents buildup of uric acid in individuals who frequently get calcium oxalate or uric acid kidney stones (including cancer patients, and those using thiazide diuretics). (See arthritis and joint pain.)

Also accepted for use as an additonal therapy for the following conditions: Chagas' disease, improve blood circulation after ischemic tissue damage, malaria (with quinine), prostate swelling (for non-bacterial prostatitis), reduce mouth sores in some chemotherapy patients, refractive epilepsy in children, restore functionality to blood vessel linings in diabetes and hypertension.

Zyloprim is only available by prescription. Use only as directed.

Zyloprim Side Effects

Adverse Side Effects:

Mild: Agitation, allergy (fever, hives, itching, rash), altered sense of taste, confusion, diarrhea, dizziness, drowsiness, hair loss on scalp (rare), nausea or vomiting, stomach cramps. Speak to your doctor if any of these possible effects should occur.

Severe:Allergy (severe skin condition), blood vessel damage or inflammation, bone marrow depression, bronchospasm, cataract formation, catatonia, chills, dark urine, hepatitis (drug-induced), high fever, joint pains, kidney damage, pale stools, peripheral neuritis (pain, tingling, or loss of sensation in extremities due to nerve damage), swollen glands, yellow skin and eyes. Any of these rare side effects indicates that you should seek emergency medical attention immediately.

Cautions: Be aware that attacks may increase for the first few weeks of treatment. This is normal and should subside with continued treatment.

This medication is not for everyone. If you have a history, or current case, of any of the following condtions, speak to your doctor about how to ensure safe and effective treatment.

• Acute Gout Attack: If you are in the midst of an attack, this is not the appropriate treatment.
• Alcohol Abuse: Untreated alcoholism could jeopardize the success of treatment, speak to your doctor about getting help with this condtion.
• Allergy: If you have ever had an allergic reaction to this medication, or have one during treatment, you will not be able to continue using it. Cross allergies with Zovirax (acyclovir) are possible. Be sure to inform your doctor of any food or dye allergies before proceeding with treatment.
• Blood Cell Disorder: Your doctor will need to determine if this treatment is safe or suitable for you.
• Bone Marrow Disorder: Your doctor will need to determine if this treatment is safe or suitable for you.
• Hemochromatosis: Discuss any family history of this disorder with your doctor before beginning treatment.
• Kidney Disease: Dosage must be adjusted down, allergic reactions more likely. Kidney damage from treatment more likely if used with thiazide diuretics, do not combine these treatments.
• Liver Disease: There are no clear guidelines for adjusting dosage in the case of liver disease, but your doctor may want to monitor your condtion more carefully, and may decide to lower your dosage.
• Low Protein Diet: Your dosage will need to be adjusted, speak with your doctor about dietary guidelines. The risk of Zyloprim toxicity is increased.
• Other Medication: Thiazide diuretics increase the risk of kidney damage, and the use of penicillin may increase the frequency of rash as a side effect. Discuss all current medications with your doctor, and be sure that any prescription or over the counter treatment you consider during therapy is discussed with your doctor.
• Pregnancy: If you are pregnant, or planning to become pregnant, speak with your doctor about the necessity of this medication. You may want to look into dietary and other means of controlling your condtion.
• Seizure Disorder: You will need to withdraw from this treatment slowly, otherwise, it could increase the risk of seizure.

Zyloprim Online - Prescriptions Through AccessMedNet

This medication should not be mixed with all other prescription or over the counter treatments. Always keep your doctor up to date on all medications you are taking, particularly when receiving a new prescription, or visiting a different doctor. Inform your doctor if you take, or plan to take, any of the following medications to ensure safe and effective treatment.

• ACE (Angiotensin-Converting Enzyme) Inhibitors - Medications like Accupril (quinapril), Aceon (perindopril), Altace (ramipril), Capoten (captopril), Lotensin (benazepril), Mavik (trandolapril), Monopril (fosinopril), Prinivil or Zestril (lisinopril), Univasc (moexipril), and Vasotec (enalapril) increase the risk of allergic reaction when used with allopurinol.
• Alcohol - As alcohol is likely to worsen gout, it should be avoided.
• Antacids - Any of prescription or over the counter antacids containing aluminum will reduce the effectiveness of your treatment.
• Anticoagulants such as Coumadin (warfarin) will need to have blood levels checked more often.
• Antidiabetic medications like Diabinese (chlorpropamide) can cause hypoglycemia when mixed with this medication. Your doctor may need to adjust your dosage.
• Benemid (probenecid) - Levels of this medication may increase.
• Cytoxan (cyclophosphamide) - This medication may build up and become toxic in combination.
• Imuran (azathioprine) - The dosage of this medication will need to be decreased.
• Iron salts - Do not combine, may be toxic to the liver.
• Lipase - This digestive enzyme may worsen gout, check all supplements, particularyl enzyme blends.
• Nolvadex (tamoxifen) - Increased risk of liver toxicity.
• Penicillin and related antibiotics can increase the likelihood of skin rash.
• Purinethol (mercaptopurine) - The dosage of this medication will need to be decreased.
• Sandimmune (cyclosporine) - This medication may build up to toxic levels when mixed with allopurinol.
• Theophylline Class Bronchodilators (Aminophylline, Dyphylline, Oxtriphylline, Somophyllin, Theo-Dur, etc...) - The effects of these drugs may be increased.
• Thiazide diuretics like Anhydron (cyclothiazide), Diuril (chlorothiazide), Enduron (methyclothiazide), Metahydrin (trichlormethiazide), Naturetin (bendroflumethiazide), Renese (polythiazide), and others may decrease kidney function, and increase the risk of kidney damage. Do not combine.
• Videx (didanosine) - Effects may be increased, especially in cases of kidney impairment.
• Vira-A (vidarabine) - Increased risk of neurotoxicity.
• Vitamin C - Doses above 2000 mg daily can increase the risk of kidney stone formation during treatment.

Zyloprim Dosages

This drug is available in 100 mg, 200 mg, and 300 mg tablets. Standard dosage guidelines for adults follow, but always follow the advice of your doctor in your individual prescription.

• Starting Dose: 100 mg, once daily. Daily dose increased by 100 mg each week until desired dose reached.
• High Uric Acid in Cancer Patients: 600-800 mg per day, divided into three doses.
• Kidney Stone Prevention: 200-300 mg, once daily.
• Mild Gout: 200-300 mg, once daily.
• Moderate to Sever Gout: 400-600 mg, once daily.

Take with food or milk to reduce stomach upset. Tablets may be broken or crushed. If you miss a dose, take it as soon as you remember, or resume your regular schedule. Doses must not be doubled.

A low purine diet is recommended with this treatment. Avoid anchovies, asparagus, lentils, liver, meat broths, mincemeat, mushrooms, mussels, peanuts, sardines, yeast, and any other foods recommended by your doctor. Also avoid alcohol, fried foods, oils that have been heated, roasted nuts, white flour or sugar, and all types of meat.

Enjoy fruit, green vegetables, starchy vegetables, rice, millet, quinuoa, corn, cheese, milk, and a moderate number of eggs. Blueberries, cherries, and strawberries are especially beneficial, but during an attack, fruits and vegetables of different types should make up the majority of your diet. Drink 2 or 3 quarts of water daily, or as much as your doctor suggests, as this will help clear uric acid from your body.

Store Zyloprim away from direct light and heat. Store in a dry location; avoid storing it in the bathroom, near sinks, or other areas where it may become damp. Do not use after the expiration date.

Keep Zyloprim away from children; both when storing it, and when discarding any unused medication.

Zyloprim and Pregnancy

Adequate studies of the safety of this medication in pregnancy are not available. It should not be used in the first trimester, and only if absolutely necessary in the remainder of the pregnancy. This treatment should not be combined with breastfeeding.

Zyloprim and Children

Only used in children when malignant growths cause uric acid buildup, and then dosage would have to be individually determined. Otherwise, Zyloprim is not recommended for this age group.

Zyloprim and Seniors

Smaller starting doses and lower maximum doses are recommended, due to decreased kidney function.

Zyloprim Online - Prescriptions Through AccessMedNet

Zyloprim is a trademark of Prometheus

Generic Allopurinol is manufactured by Mylan, Par, and Watson

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This document is provided for information only. It is not a substitute for consultation with a physician, either to diagnose symptoms or prescribe treatment. Any dosages mentioned are general guidelines only, please follow the directions of your doctor or pharmacist exactly when taking medication. We have made every effort to ensure that this information is accurate, but only your doctor can say if a medication, or drug combination, is safe for you. Information intended for US residents only.