About Valium
Valium is a muscle relaxant and anti-anxiety medication, also occasionally
used to treat sleep disorders. Valium is in the group of drugs known
as benzodiazepines, a class of antidepressants, anti-panic agents,
and muscle relaxants. Valium is only available by prescription.
Valium slows the central nervous system, and is prescribed for
anxiety related disorders and conditions that cause severe muscle
spasms and convulsions. Valium can cause withdrawal symptoms if
stopped abruptly, always follow your doctor's guidelines concerning
how much to take, and when and how to stop treatment with Valium.
Certain patients have conditions that make Valium an unsuitable
treatment, so discuss any allergies or other medical conditions
you may have with your doctor when planning your treatment.
Use: Do not use with other sedatives, narcotic pain medications,
or alcohol. Store Valium away from light and heat.
Valium Side Effects
Common Valium side effects might include: drowsiness, fatigue, light-headedness, and loss of coordination. Operating automobiles or heavy machinery is not recommended while taking Valium. Be aware of how this medication affects you before attempting any potentially dangerous activities.
Less common Valium side effects: abdominal cramps, constipation,
dry mouth, hyperventilation, blurred vision, nausea, chest pain,
change in sex drive, confusion, headache, change in appetite, insomnia,
unusual dreams, change in salivation, low blood pressure, racing
heartbeat, fainting, nasal congestion, difficulty urinating, sweating,
weight change, skin irritation, twitching or tremors, nervous or
anxious state, sun sensitivity, respiratory infection, memory impairment,
menstrual difficulties, and loss of coordination. Speak to your
doctor about any of these effects; your dosage may need to be adjusted
or treatment discontinued.
Rare Valium side effects: difficulty concentrating, slurred
or unusual speech, double vision, fear, altered sense of taste,
lack of inhibition, muscle cramps or spasms, urination problems,
tingling, incontinence, warmth, weakness, change in muscle tone,
or yellow eyes and skin. Speak to your doctor if you experience
any of these effects; your treatment may need to be discontinued.
Valium treatment should be discontinued if any of the following occur: hyperexcitement, muscle spasm, anxiety, hallucinations, rage, tremors, insomnia, sleeping difficulties or overstimulation.
Cautions: Valium has been known to interact undesirably with certain medical conditions. Tell your doctor if you have, or have a history of, any of the following conditions:
- Alcohol or drug abuse - may increase likelihood of Valium dependence
- Allergic reaction to Valium, or other benzodiazepine. Always
tell your doctor about any allergies before starting a medication.
- Brain disease - may increase likelihood of side effects from
Valium
- Breathing difficulties such as asthma, bronchitis, emphysema,
or any other chronic lung disease - Valium may worsen this condition.
- Difficulty swallowing - This condition may become more pronounced
in children.
- Epilepsy or seizures - Abruptly starting or stopping treatment
with Valium may increase seizures. Although Valium can be used
as an aid to anti-convulsive therapy, it should be used cautiously
and strictly according to a doctor's instructions in these cases.
- Glaucoma - Valium should not be prescribed to patients with
acute narrow-angle glaucoma. Patients receiving treatment for
open angle glaucoma should consult their doctor, as Valium may
be an acceptable treatment for them.
- Hyperactivity
- Kidney or liver problems - In isolated cases, Valium has been
reported to cause jaundice. If you experience yellowing of the
skin or eyes, seek medical treatment immediately. More Valium
may end up in your bloodstream if you have a pre-existing kidney
or liver condition, increasing the likelihood of side effects.
- Major Depression - The central nervous system depressant effects
of Valium may worsen this condition.
- Myasthenia gravis - This autoimmune disorder characterized by
muscle weakness may be aggravated by Valium treatment.
- Porphyria - Valium (diazepam) is listed as an unsafe drug for
porphyria, an enzyme deficiency that can cause fragile skin that
is sensitive to sunlight, digestive difficulties, anxiety, and
reddish-brown urine.
- Psychosis or other serious mental illness - Valium has not proved
to be an effective treatment for these conditions, and is not
recommended.
- Sleep apnea (temporary suspension of breathing during sleep)
- Valium may worsen this condition. Individuals with sleep apnea
should not generally use sedatives as sleep aids. (See Sleep Disorders)
Valium Dependence: Valium has been known to be habit-forming.
Withdrawal symptoms may occur if treatment is discontinued abruptly.
Follow your doctor's advice about how much, and how often, you should
take Valium. If you are considering stopping Valium treatment, ask
your doctor how to safely decrease and then stop Valium.
Physical withdrawal symptoms should not be interpreted as addiction
unless you crave the medication even when you feel well, or desire
to take it more often than suggested by your doctor. Physical withdrawal
is common in individuals who have been taking Valium for long periods
of time, and can be minimized by following your doctor's advice.
Valium Interactions
Valium slows the central nervous system, and should be taken with
care with medications that do the same thing. When Valium is taken
with certain other medications, the rate of side effects may increase,
and the action of either medication may be increased or altered.
Certain medications can cause an undesirable build-up of Valium
in the body. Stimulants may decrease the effectiveness of your treatment.
Read the labels of herbal supplements and over the counter medications
to check for interactions. Ask your doctor's advice about combining
Valium with any of the following:
- Alcohol - Valium treatment should not be mixed with alcohol,
it increases the risk of overdose and fatal toxicity. Avoid alcohol
at all times while taking Valium.
- Any medication which may cause drowsiness
- Antabuse (disulfiram)
- Antiseizure medication like Cerebyx (fosphenytoin), Dilantin
(phenytoin), or Tegretol (carbamazepine) may build up to toxic
levels when taken with Valium.
- Benzodiazepines of any other type such as Ativan
(lorazepam), bromazepam,
Halcion (triazolam),
Restoril (temazepam),
Librium (chlordiazepoxide),
nitrazepam, Xanax
(alprazolam), Tranxene-SD (clorazepate), Paxipam (halazepam),
ProSom (estazolam), Klonopin
(clonazepam), and others, should not generally be mixed
with Valium (diazepam). This could lead to extreme oversedation,
overdose, or possibly death.
- Benemid (probenecid)
- Beta blockers like Lopressor (metoprolol) or Inderal (propranolol)
- Desyrel (trazodone)
- Ephedra - This stimulant may reduce the sedative effects of
Valium.
- Ginseng - This herb may interfere with Valium treatment.
- Gotu kola - This herb may decrease the effectiveness of Valium.
- Kava kava - Do not take this herb while taking Valium.
- Kola nut - This herb may cause diazepam to be less effective.
- Lanoxin (digoxin)
- Larodopa or Sinemet (carbidopa, levodopa)
- Ma huang - This herb may decrease the effectiveness of Valium.
- MAO inhibitors - Valium should not be mixed with MAO (monoamine
oxidase) inhibitors, a class of antidepressants and antisenility
drugs, such as Eldepryl (selegiline), Furoxone (furazolidone),
Nardil (phenelzine), Marplan (isocarboxazid), or Parnate (tranylcypromine).
- Mate - This herb may decrease the effectiveness of Valium.
- Morphine and Valium must not be administered together.
- Narcotic analgesics of any kind, like Darvon (propoxyphene),
Darvocet (propoxyphene, acetaminophen), Demerol
(meperidine), Codeine, Percocet
(oxycodone, acetaminophen), Vicodin
(hydrocodone and acetaminophen), Vicoprofen
(hydrocodone and ibuprofen), or OxyContin
(oxycodone) may accelerate central nervous system or respiratory
depression when taken with Valium. Also, Valium may decrease the
effectiveness of these medications as pain relievers.
- Nicotine - May reduce the effectiveness of Valium.
- Nizoral (ketoconazole)
- Norflex (orphenadrine)
- Risk of oversedation.
- Oral contraceptives - May cause Valium to build up in the body,
potentially increasing side effects.
- Prilosec (omeprazole)
- Provigil (modafinil) -
Dosage adjustments may be necessary.
- Rifamate (isoniazid), Rifater or Rifadin (rifampin), or Mycobutin
(rifabutin)
- Sedatives like Fioricet
(butalbital, acetaminophen, and caffeine), Fiorinal
(butalbital, aspirin, and caffeine), Phenobarbitol, Seconal, or
other barbiturates.
- Selective serotonin reuptake inhibitors (SSRIs) like Celexa
(citalopram), Paxil (paroxetine),
Prozac (fluoxetine), Luvox (fluvoxamine), or Zoloft (sertraline).
- Serzone (nefazodone)
- Skeletal muscle relaxants such as Flexeril
(cyclobenzaprine), Skelaxin
(metaxalone), Soma (carisoprodol),
or Robaxin (methocarbamol)
may cause oversedation in combination with this medication.
- Sleep medication like Ambien
(zolpidem), Sonata (zaleplon),
or over the counter sleeping pills should be used with Valium
only as, and if, advised by your doctor.
- Sporanox (itraconazole)
- St. John's Wort - Do not take this herb while taking Valium.
- Tagamet (cimetidine)
- Tranquilizers such as Haldol (haloperidol), Mellaril (thioridazine),
or Thorazine (chlorpromazine) may cause oversedation.
- Tricyclic antidepressants such as Elavil
(amitriptyline), Asendin (amoxapine), Anafranil (clomipramine),
Pertofrane or Norpramin (desipramine), Sinequan
(doxepin), Tofranil (imipramine), Aventyl or Pamelor (nortriptyline),
Vivactil (protriptyline), and Surmontil (trimipramine), may increase
the risk of side effects from Valium.
- Ultram (tramadol) - This
pain reliever may oversedate you if taken in combination with
diazepam.
- Valerian - Do not take this herb while taking Valium.
- Valproic acid, also Depakote, Depakene, and divalproex.
- Zantac (ranitidine)
Valium Dosages
Valium is available in scored tablets in dosages of 2mg (white),
5mg (yellow), and 10mg (blue).
Diazepam dosage and tablet availability may be different if the
tablets are not manufactured under the Valium brand name.
Therapeutic dosages of Valium rarely exceed 10 mg, taken 4 times
per day. Higher dosages are not recommended as they can increase
the risk of dependence, and the likelihood of acute withdrawal symptoms
if the drug is discontinued abruptly. Do not take two doses of Valium
at the same time.
Valium overdose symptoms can include confusion, sleepiness, or coma. Seek medical treatment immediately if you suspect an overdose.
Valium and Pregnancy
Valium has been known to increase the risk of birth defects when taken in the first trimester of a pregnancy. It is not recommended for pregnant women, or women who are planning to become pregnant.
Valium and Children
Valium is not recommended for children under six months of age. Older children should be started on the lowest dose possible (1-2 mg) and increased only as needed. Valium is not usually recommended as a long term treatment for children.
Valium and Seniors
Older adults taking Valium are usually encouraged to start with smaller doses (2-2.5 mg) and limit intake to the smallest effective dose. Seniors are more likely to become too heavily sedated, or experience decreased muscle coordination.
What Valium Treats
Valium is currently prescribed as a treatment for:
- Anxiety disorders and temporary relief for symptoms of anxiety.
Depending on symptoms, 2-10 mg, 2-4 times per day.
- Symptom relief for acute alcohol withdrawal. 10 mg, 3-4 times
within first 24 hours, then reducing to 5 mg, 3-4 per day as necessary.
- As an aid to the relief of skeletal muscle spasm and tremor
as in cerebral palsy. (Valium is not a complete therapy for these
sorts of disorders.) 2-10 mg, 3-4 times per day.
- As an aid to treatment of convulsive disorders such as epilepsy.
(Valium is not a complete therapy for these sorts of disorders,
and may be mixed with another medication.) 2-10 mg, 2-4 times
per day.
- Valium may be prescribed in low doses to treat the symptoms
of fibromyalgia.
Valium is a trademark of Roche Pharmaceuticals
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This document is provided for information only. It is not a substitute
for consultation with a physician, either to diagnose symptoms
or prescribe treatment. Any dosages mentioned are general
guidelines only, please follow the directions of your doctor
or pharmacist exactly when taking medication. We have made
every effort to ensure that this information is accurate,
but only your doctor can say if a medication, or drug combination,
is safe for you. Information intended for US residents only.
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