About Altace
This drug is an ACE (Angiotensin Converting Enzyme) Inhibitor.
These medications work to block an enzyme system, which then
allows artery walls to relax, reducing blood pressure. This
class of drug is recommended for individuals who wish to be
able to exercise more normally.
Altace treatment will not cause increases in blood pressure
if stopped suddenly, has less impact on the liver than many
medications, and is not a problem for patients with asthma,
diabetes, or high cholestorol.
Altace is prescribed to treat: advanced heart failure, high
blood pressure (any level), reduce the risk of death after
congestive heart failure or heart attack, and may be a treatment
well-suited for diabetics with kidney problems. This particular
ACE inhibitor has shown good results in decreasing the risk
of death due to cardiovascular incidents in individuals with
coronary artery disease, diabetes, or peripheral vascular
disease, even those who have multiple risk factors. It has
tested very favorably in the African American population for
decreasing the risk of death due to kidney disease. You will
know if treatment will be effective within a few weeks, but
as there is no cure for high blood pressure, you may need
to take this medication on a permanent basis.
Altace is only available by prescription.
Altace Side Effects
Expected Side Effects: Constipation, cough, dizziness,
fainting, lightheadedness, nausea, scalding sensation in mouth.
Adverse Side Effects: The following side effects should
be reported to your doctor immediately, or medical advice
sought if your doctor is not available. If they are serious,
you will need to contact emergency personnel and seek treatment
at once.
Mild: Abdominal pain or discomfort, allergy (itching,
psoriasis, rash), altered sense of taste, fainting, fast heartbeat
when standing, headache, increased risk of infection, joint
pain, nightmares, ringing in ears, sores on mouth or tongue,
swelling in extremities. Report infection or swelling to your
doctor at once.
Severe: Allergy (swelling of face, tongue, and/or
throat, possibly life threatening), anemia, bone marrow depression
(bleeding or bruising, fever, sore throat, weakness), fluid
retention around heart, high potassium levels, liver damage,
Lupus or other severe skin problems, pancreatitis. These severe
side effects are classed as rare, or may have only occurred
in isolated case reports, but be alert for them and get all
tests and check-ups as recommended by your physician.
Undesirably High Levels of Potassium: Confusion, difficulty
breathing, irregular heartbeat, nervousness, numbness or tingling
(feet, hands, lips), shortness of breath, weakness or heavy
sensation in legs.
Cautions: This medication may not be suitable for
everyone, and certain individuals may require dosage adjustments
or more careful medical supervision. To ensure the maximum
safety and effectiveness of treatment, discuss any current
instances or medical history of the following.
- Allergies: Any allergic reaction to an ACE inhibitor
means that you should not use the drug again. The development
of swelling of the tongue, face, or throat should be reported
to medical personnel at once, and you should stop taking
the medication immediately. Inform your doctor of any food
or dye allergies, this might influence a decision on which
formulation of the treatment to use.
- Bee Sting Allergy - If you had an allergic reaction
during therapy to reduce sensitivity to bee stings, you
should inform your doctor before beginning treatment.
- Blood or Bone Marrow Disease - Do not use.
- Diabetes - Dosage adjustments may be necessary.
ACE inhibitors are preferred by some doctors for the treatment
of high blood pressure in diabetics who have protein in
the urine.
- Heart Attack: Under a doctor's supervision, may
be given within 24 hours of heart attack, after the heart
has stabilized. The usual dose is 5 mg daily if it seems
effective, increased to 10 mg daily for 6 or more weeks
to prevent recurrence.
- Kidney Problems: Lower doses will be necessary,
usually from 2.5 mg-5 mg. Your doctor will advise you regarding
a safe and effective amount. A therapeutic combination of
this drug with hydrochlorothiazide should not be used, as
the thiazide diuretics are less effective in this case than
loop diuretics.
- Liver Disease - Altace has minimal impact on the
liver, but your condition should be discussed with your
doctor.
- Low Sodium Diet - May increase risk of high blood
levels of potassium. Speak with your doctor about the best
course of treatment.
- Lupus - Speak to your doctor, this treatment may
or may not be suitable for you.
- Medical Tests - This medication may alter results
on a number of medical tests. Inform the lab technician
that you are using an ACE inhibitor before your test.
- Other Medications - Any other prescription or over
the counter medications that you take or may plan to take
should be discussed with your prescribing physician and
pharmacist. It's particularly important to mention treatments
for high blood pressure, including diuretics, nitrates,
drugs that supress the immune system, gout medication, anti-inflammatories
(NSAIDs), or potassium supplements.
- Potassium - If your blood levels of potassium are
very high, you should not use an ACE inhibitor.
- Pregnancy - ACE inhibitors are not generally advised
during pregnancy, and should not be taken at all during
the last two trimesters (6 months). Speak to your doctor
about safety precautions if you intend to breastfeed.
- Renal Artery Stenosis - Speak with your doctor
about this condition before deciding on a treatment.
- Scleroderma - Speak to your doctor, this treatment
may or may not be suitable for you.
- Surgery - If you will have any type of surgery
or dental work performed under general anesthesia, it is
important for your safety that your surgeon and anesthesiologist
be aware that you use this treatment.
Altace Interactions
This medication may not mix well with all prescription and over the counter treatments, be sure to discuss with your doctor and pharmacist any other treatments you may plan to take, especially any of the following.
- Alcohol - May lower blood pressure even further. Speak
with your doctor about recommended use.
- Anafranil (clomipramine) - This medication may build up
to toxic levels, and cause wild mood swings.
- Antacids - May decrease absorption. Do not use within
two hours of taking your medication.
- Aspirin, salicylic acid, or other salicylates - ACE inhibitor
treatment may be less effective.
- Cotrimoxazole - May increase blood levels of potassium
and the risk of disturbances in heart rhythm.
- Cox II inhibitors like Celebrex
(celecoxib) and Vioxx (rofecoxib)
may make ACE inhibitors less effective.
- Diuretics (loop) - Drugs like Bumex (bumetanide) or Lasix
(furosemide) may result in very low blood pressure when
standing.
- Diuretics (potassium sparing) - Drugs like Aldactazide
(spirinolactone), Dyazide (triamterene), or Moduretic (amiloride)
may increase potassium levels and the risk of disturbances
in heart rhythm.
- Diuretics (thiazide) - Drugs like hydrochlorothiazide
may result in higher levels of medication in your body,
which may be used therpeutically.
- Erythropoietin - This medication may be less effective
when taken with an ACE inhibitor.
- Glucophage (metformin) - May cause high potassium levels
or lactic acidosis when diabetic patients combine these
treatments.
- Imuran (azathioprine) - Risk of severe anemia.
- Interferons (alpha, & beta) - Do not combine, high
risk of blood disorders when these medications are used
together.
- Iron, supplemental - Do not take within 2 hours of an
ACE inhibitor, this mineral may decrease symptoms of cough
that can develop with long-term use. Do not use supplemental
iron without the supervision of a doctor, high levels may
be dangerous.
- Lithium - Toxic levels of this
drug may build up, the combination is not generally advised.
- Low salt milk - Increases risk of high blood levels of
potassium.
- Mycobutin (rifabutin) - ACE inhibitors may be less effective.
- Narcan (naloxone) - May decrease effectiveness of treatment.
- Non-Steroidal Anti-Inflammatories, or NSAIDs, such as
Butazolidine (phenylbutazone), Clinoril
(sulindac), Ibuprofen (Motrin), Indocin (indomethacin),
Feldene (piroxicam), Naprosyn (naproxen), Toradol
(ketorolac), and others may decrease the effectiveness
of treatment.
- Phenothiazines - Medications like Compazine (prochlorperazine),
Mellaril (thioridazine), Phenergan (promethazine), Prolixin
(fluphenazine), Serentil (mesoridazine), Sparine (promazine),
Stelazine (trifluoperazine), Temaril (trimeprazine), Tindal
(acetophenazine), Thorazine (chlorpromazine), Trilafon (perphenazine),
and Vesprin (triflupromazine). These tranquilizers and antipsychotics
increase the risk of low blood pressure when standing in
combination with ACE inhibitors.
- Potassium - Do not take any supplements containing potassium
without the approval of your doctor. Individuals using ACE
inhibitors are at risk for elevated levels of blood potassium.
- Rifadin (rifampin) - ACE inhibitors may be less effective.
- Salt substitutes - Increases risk of high blood levels
of potassium.
- Sandimmune (cyclosporine) - May cause delayed kidney failure.
- Zyloprim (allopurinol) - Increased risk of serious skin
reactions.
Altace Dosages
Altace is available in 1.25 mg, 2.5 mg, 5 mg, & 10 mg capsules.
Typical starting dose is 1.25 mg - 2.5 mg daily. Usual ongoing
adult dose is 2.5 mg - 20 mg once daily, taken in one dose.
Altace Directions
For best results, take your medication at the same time every
day.
If you miss a dose, take it as soon as you remember. If it's
nearly time for your next dose, skip the missed dose and resume
your regular schedule. Do not take double doses, or change
your dose without permission from your doctor. Sudden changes
in blood pressure are undesirable, and may put elderly patients
at greater risk of stroke or heart attack.
Capsules may be taken with or without food, and they may
be opened to aid consumption. If an extended release form
should come on the market, however, consult the instructions
on the packaging. Extended release medications should generally
be taken as is, and may be less effective or cause overdose
if crushed.
Store Altace away from direct light and heat. Store in a dry location; avoid storing it in the bathroom, near sinks, or other areas where it may become damp. Do not use after the expiration date.
Keep Altace away from children; both when storing it, and when discarding any unused medication.
Altace and Pregnancy
During the first trimester, this medication should only be
used if absolutely necessary. Use during the last two trimesters
of pregnancy could potentially inflict severe bone deformations,
low birth weight, or death on the unborn child.
If you are breast-feeding, seek your doctor's advice. Not
absolutely contraindicated, but infant should be monitored
closely.
Altace and Children
The safety and effectiveness of these medications in individuals under the age of 18 has not been adequately studied.
Altace and Seniors
ACE inhibitors should be started in the smallest possible doses. Sudden changes in blood pressure, including rapid decreases, can increase the risk of heart attack or stroke.
Altace is a trademark of Monarch
Back to top
This document is provided for information only. It is not a substitute for consultation with a physician, either to diagnose symptoms or prescribe treatment. Any dosages mentioned are general guidelines only, please follow the directions of your doctor or pharmacist exactly when taking medication. We have made every effort to ensure that this information is accurate, but only your doctor can say if a medication, or drug combination, is safe for you. Information intended for US residents only.
|